Promethazine is contraindicated in comatose states, and in men and women recognized to be hypersensitive or to own had an idiosyncratic reaction to promethazine or to other phenothiazines.
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Animal copy research haven't been carried out With all the drug mixture-promethazine and codeine. It isn't known whether this drug mix can result in fetal harm when administered to your pregnant female or can have an impact on replica ability.
Although antihistamines are actually located to create fetal mortality in rodents, the pharmacological results of histamine from the rodent do not parallel Those people in guy. There isn't any satisfactory and perfectly-controlled studies of promethazine in pregnant Ladies.
Promethazine hydrochloride and codeine phosphate ought to be given to the pregnant lady only if Evidently required.
The estimated history hazard of important start defects and miscarriage to the indicated inhabitants is unknown. All pregnancies Possess a history hazard of beginning defect, loss, or other adverse results.
The remedy of overdosage with promethazine and codeine is basically symptomatic and supportive. Only in scenarios of extreme overdosage or personal sensitivity do critical website signs which includes respiration, pulse, blood pressure level, temperature, and EKG must be monitored. Activated charcoal orally or by lavage may be offered, or sodium or magnesium sulfate orally like a check here cathartic. Focus needs to be specified towards the reestablishment of sufficient respiratory exchange through provision of the patent airway and establishment of assisted or managed air flow.
The diagnostic analysis of people using this type of syndrome is challenging. In read more arriving at a diagnosis, it is vital to recognize circumstances the place the scientific presentation incorporates both serious health-related sickness (eg.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers below 6 many years of age, for the reason that the combination could lead to lethal respiratory melancholy With this age inhabitants. It can be crucial that promethazine with codeine syrup is calculated with an accurate measuring product (see Safety measures-Facts For People).
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Respiratory melancholy bringing about arrest, coma, and Dying has transpired with the use of codeine antitussives in youthful small children, specially while in the beneath-one-12 months infants whose power to deactivate the drug will not be totally formulated.
By no means use this medication in much larger quantities, or for for a longer period than prescribed. Tell your health click here practitioner In the event the medication seems to end Doing the job as well in relieving your discomfort.
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Narcotic analgesics trigger get more info histamine release, which seems to be answerable for wheals or urticaria in some cases seen at the site of injection on parenteral administration.